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Instability of almost all joints can occur, but appears most often in the lower and upper extremities, with the wrist, fingers, shoulder, knee, hip, and ankle being most common
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Thus, the protective effects of metformin on palmitate-induced cell death could result from partially inhibiting mitochondrial complex I, which would restore mitochondrial function and demonstrate the necessity of mitochondrial complex I in retarding or stopping the progression of NAFLD (32)
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