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Frontiers | Revealing the contribution of astrocytes to glutamatergic neuronal transmission
This creates a positive feedback loop where COX-2 activity is further boosted increasing the production of pro-inflammatory prostaglandins, which exacerbate oxidative stress and tissue damage (Simmons et al., 2004
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Its effects are mediated through two types of receptors: Nuclear receptors, which induce gene expression changes, and membrane receptors, located at the cell surface and mediate non-genomic vitamin D effects such as bone metabolism and regulation of calcium homeostasis[88]
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