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FIGURE 3 3.4 Downstream effectors of the integrated stress response are upregulated following chronic exposure to DTG Given the upregulation of ATF4 and its target genes detected in the RNA-seq analysis and previous reports showing that some ART drugs lead to activation of the ISR in cultured rat neurons (Stern et al., 2018), we next considered whether any downstream effectors of the ISR could play a role in the deficits we observed
Epitalon
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