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Elevated levels of F2 isoprostanes (prostaglandin-like substances derived from lipid peroxidation) in serum and urine from SLE patients have been reported [43]
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In a murine arterial stiffness model, a SIRT1 gain-of-function protected against nicotine-induced arterial stiffening, and nicotine was shown to increase vascular iNOS and 3-nitrotyrosine and was mechanistically connected to peroxynitrite-mediated SIRT1 inactivation, thereby placing RNS as a functional driver of disease-related vascular remodeling 101
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