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As described previously, the major part of exogenous cystine is incorporated in GSH, yet unexpectedly, the remaining part is incorporated in co-enzyme A synthesis via the pantothenate pathway (69)
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The possible mechanisms for the generation of acanthocytes include abnormal phospholipid metabolism and an increased ratio of cholesterol to phosphatidylcholine in the cell membrane, both of which can cause abnormalities in the erythrocyte membrane ( In HAPC rats, an increase in EOF was observed, accompanied by decreased resistance of cells to hemolysis in hypotonic solutions
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