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In the normal physiological reaction catalyzed by kynureninase, a quinonoid intermediate is converted to an enamine intermediate with resonance stabilized partial carbanion character at the terminal carbon (Eq
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Additionally, most existing systems rely on the inherent high ROS environment at the lesion site to achieve targeted release (Yan et al., 2024), but this passive targeting strategy may have limited efficacy in the early or mild stages of the disease
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