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However, in Sequence 2 (i.e., GSH-C4-first) exhibited a significant median increase of 3 mm from baseline to the intermediate assessment (p = 0.0345)

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Although iron death-targeting interventions, including iron chelators, GPX4 agonists, lipid peroxidation scavengers, natural bioactive compounds (e.g., curcumin, resveratrol), and nanodelivery systems, show promise in preclinical studies, the cell type specificity and context dependency of ferroptosis pose critical challenges for precise intervention