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Indeed, previous studies have shown an inverse correlation between PK activity and reticulocyte counts or the reduction in eosin-5′-maleimide binding or the mount of spherocytes in patients with HS (27–29) In the present study, we tested the effectiveness of mitapivat in a mouse model of HS and show that mitapivat metabolically reprograms RBCs in HS
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5 Discussion Metabolic reprogramming is essential for the advancement of tumors and has become a central topic in cancer research lately (109)
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