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A 2019 review from Loughborough University in the UK, outside the Zagreb group, found the results consistently positive

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Additionally, statins, inhibitors of the MVA pathway, may mitigate inflammation by inhibiting HMG-CoA reductase, thereby decreasing downstream metabolites of the MVA pathway and modulating the immune response (96).There are also some unresolved issues in the study of the antioxidant system in RA.For example, the degree of activation of the Nrf2 signaling pathway in RA and the mechanism of its interaction with other signaling pathways are still not fully understood.In addition, although several studies have shown that there is an imbalance of the antioxidant system in RA patients, there is still a lack of effective strategies and methods on how to precisely regulate the antioxidant system for the purpose of treating RA ( Figure 2 )