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Spermidine enhances autophagy by modulating several key signalling pathways, including the AMP-activated protein kinase (AMPK) pathway and the SIRT1 pathway, both of which are central regulators of energy metabolism, stress responses and cellular longevity (Reference Jeong, Cha and Han21)
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In addition, in a rat liver transplantation model using healthy and steatotic livers, the cytosolic and mitochondrial SOD delivered with adenovirus ameliorated the graft survival [230]
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