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2.2 In vivo models In the last 30 years numerous animal models for CF have been developed for research purposes
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Upon delivery of B12 to the tissues by holo TC, receptor-mediated endocytosis occurs, after which holoTC enters acidic lysosomes where the transcobalamin protein is degraded, the B12 is released, and then converted to its cofactor forms (Allen et al., 2018)
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