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It remains unclear why certain 5-HT 2A receptor ligands can promote neuroplasticity and induce sustained therapeutic behavioral effects without producing hallucinogenic responses, while other 5-HT 2A agonists fail to promote plasticity altogether
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Its synthesis may involve the regulation of the hypothalamic pituitary adrenal axis (HPA axis), but the specific synthesis enzyme system and regulatory mechanism have not been fully elucidated
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