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Some factors associated with B12 deficiency include: Problems absorbing nutrients Pernicious anemia Certain gastrointestinal conditions Some gastrointestinal surgeries Certain medications Low dietary intake The NIH notes that factors such as gastrointestinal surgery, pernicious anemia, and prolonged use of certain medications can contribute to B12 deficiency

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This likely accommodates the essential role of Egr1 indirectly controlling the expression of other genes, and thereby, neural activity, neural plasticity, and learning (Knapska & Kaczmarek, 2004), similar to the implied role of Egr1 gene in inflammation, myocardial injury (Rayner et al., 2013), brain injuries following transient focal ischemia (Tureyen, Brooks, Bowen, Svaren, & Vemuganti, 2008) or permanent occlusion of the middle cerebral artery (Beck, Semisch, Culmsee, Plesnila, & Hatzopoulos, 2008)