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A recent study integrating genome-wide association studies with single-cell transcriptomic data from the mouse nervous system revealed that PD is genetically associated not only with cholinergic and monoaminergic neurons, as expected, but also, unexpectedly, with OLs ( LRRK2 gene, which encodes leucine-rich repeat kinase 2 and which is associated with both familial and sporadic PD ( The myelination status or the degree of myelination has been suggested as a key factor determining neuronal vulnerability to Lewy pathology in PD (Orimo et al., 2011), along with other features, such as long highly branched axons, autonomous activity, calcium-dependent pacemaking, and high levels of oxidative stress (Volpicelli-Daley et al., 2014)
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PMCID: PMC8391 Modi BP, Khan HN, van der Lee R, Wasim M, Haaxma CA, Richmond PA, Drögemöller B, Shah S, Salomons G, van der Kloet FM, Vaz FM, van der Crabben SN, Ross CJ, Wasserman WW, van Karnebeek CDM, Awan FR
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