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Experimental studies have shown that glutathione depletion impairs macrophage phagocytosis, intracellular killing, and antigen presentation, weakening immune surveillance and pathogen clearance [4]
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In obese individuals, insulin resistance has been shown to be linked to increased release of adipocyte-derived bioactive metabolites like lipids, free fatty acids, monocyte chemoattractant protein-1 and pro-inflammatory cytokines [31]
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