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have extensively functionally characterized the DUF1490 immediately in front of CtpC, a P 1B-6 -like ATPase transporter that harbors a canonical P 1B-1 - and P 1B-2 CPC motif in the TM4 associated with Cu I an Zn II transporters (Figure 54, bottom ), but contains a canonical P 1B-6 -class TxxNHN motif in TM6 (Figure 56A), consistent with a global SSN analysis that places these CPC enzymes in their own cluster of closely related sequences