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These microorganisms can produce a variety of metabolites, including short-chain fatty acids (SCFAs), ammonia, and sulfur compounds ( The functions of SCFAs are involved in modulating energy metabolism, regulating immune and inflammatory responses, and inhibiting oxidative stress and mitochondrial damage, which are mainly achieved through the activation of transmembrane G protein-coupled receptors (GPRs) and the inhibition of histone acetylation (HDAC) ( 2 MetS and kidney diseases 2.1 The definition of MetS The concept of “MetS” was initially introduced by Grundy and colleagues in 2001 ( 2.2 The correlation between MetS and CKD The kidney has a crucial role in metabolism, and an expanding body of evidence indicates that individuals with MetS are at a higher risk of developing CKD, which is characterized by impaired renal function and structural damage

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