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Homolytic cleavage of peroxynitrite can produce • OH and • NO 2 , (205) which react together to form nitrate, to reform HOONO (cage return), or diffuse apart, leaving free radicals that can cause other oxidative events
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Apparently, the de novo missense mutations examined in these patients maintain the functionality of the Drp1 protein, thereby preserving mitochondrial respiration and leading to extended life expectancy into childhood or early adolescence
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