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It was associated with decreased 24S-OHC levels and increased cholesterol content in neurons (168, 169) or HD ( in vitro ( via ROS accumulation during aging results in decreased cholesterol levels in neuron plasma membrane, via 24S-OHC efflux, favoring the recruitment of TrkB and the activation of the PI3K/Akt pro-survival pathway ( per se could also be implicated, regarding the known roles of cholesterol in neuronal membranes (55)
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Variation:100ml
doi: 10.1038/s41590-021-00886-5
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