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Part of this defensive pathway, which needs to be fully determined, may be the already mentioned BPC 157 effects: activation of the Src–caveolin-1–eNOS pathway [29], activation of the VEGFR2–Akt–eNOS signalling pathway without the need of other known ligands or shear stress [33] and membrane stabilisation [37]
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Endoneurial microangiopathy, characterized by capillary abnormalities, occurs early in DPN and correlates with clinical, neurophysiological, and morphological abnormalities
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