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Key dosing points from the study: Dose range: 200–500 mcg per session (individual variation based on severity and body weight) Frequency: 2–3 sessions per week during the active treatment phase Duration: 4–8 weeks of active treatment Route: Local subcutaneous injection proximal to the affected joint Concurrent therapy: Most patients continued physical therapy alongside BPC-157 treatment The combination of local administration and physical therapy aligns with the hypothesis that BPC-157 accelerates structural repair while functional loading (exercise) guides proper tissue remodeling

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Despite this, nephrotoxicity is a well-known side effect of its use in chemotherapy [96–100]